Konstantin F. Jendretzky¹, Anna Bajor², Lisa‑Marie Lezius¹, Martin W. Hümmert¹, Franz Felix Konen¹, Gerrit M. Grosse¹, Philipp Schwenkenbecher¹, Kurt‑Wolfram Sühs¹, Corinna Trebst¹, Carsten Framme², Mike P. Wattjes³, Sven G. Meuth⁴, Stefan Gingele^1,5 & Thomas Skripuletz^1,5

Optic neuritis is often an initial symptom in multiple sclerosis (MS) or clinically isolated syndrome (CIS), yet comprehensive studies using the 2017 McDonald criteria for MS are scarce. Patient records from our academic centre (2010–2018) were reviewed. Using the 2017 McDonald criteria, three groups were formed: MS optic neuritis (optic neuritis with confirmed MS), CIS optic neuritis (optic neuritis without confirmed MS) and suspected optic neuritis (sON). We compared clinical and paraclinical findings among the groups to identify predictors for CIS‑ or MS‑optic neuritis. The study included 129 MS, 108 CIS, and 44 sON cases. The combination of visual impairment, dyschromatopsia, and retrobulbar pain was observed in 47% of MS patients, 42% of CIS patients, and 30% of sON patients. Dyschromatopsia was the strongest indicator of MS or CIS diagnosis in the backward regression model. 56% of MS patients had relative afferent pupillary defect, 61% optic nerve anomalies within magnetic resonance imaging, and 81% abnormal visual evoked potentials. Our results emphasize the challenges in diagnosing optic neuritis, as not all patients with objectively diagnosed MS exhibit the triad of typical symptoms. To address potentially missing clinical features, incorporating additional paraclinical findings is proposed.

Keywords Optic neuritis, Multiple sclerosis, Clinically isolated syndrome, McDonald Criteria, Diagnostic teria

GKB-NON-2024-00556